Peptic Ulcer Disease – Medical Disorders

Medical Disorders

Peptic ulcer disease (PUD)

What type of disorder do you have?

Peptic ulcer disease can affect the stomach (gastric ulcer) or duodenum (duodenal ulcer).

It is believed that Helicobacter pylori is the causative pathogen, and that PUD can be exacerbated by cigarette smoking and NSAID use.
The incidence of PUD among individuals with kidney disease and a history of chronic alcohol abuse is increasing.

10%-20% of individuals with PUD may develop life-threatening complications such as hemorrhage, perforation, or obstruction.

A less-frequent stomach disorder is inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease.

Do you have signs or symptoms associated with your disease?

Symptoms of gastric ulcers may include retrosternal chest discomfort, epigastric pain radiating to the back that is aggravated by food, nocturnal pain, nausea and vomiting, early satiety, or postprandial distress.

Epigastric pain associated with duodenal ulcers are described as a burning sensation accompanied by nausea and vomiting. The symptoms typically start when the stomach is empty and are alleviated by ingestion of antacids, milk, or food.

What type of medications do you take?

Peptic ulcers are managed with a variety of medications. The most common type of medication is protein pump inhibitors (PPI)s), such as Omeprazole (Prilosec), Esomeprazole (Nexium), Lansoprazole (Prevacid), Pantoprazole (Protonix), Rabeprazole (Aciphex) and Dexlansoprazole (Dexilant). Other medications may include antibiotics to eliminate the causative bacteria, antacids to buffer gastric acid, mucosal protective agents, anticholinergic agents to decrease gastric acid production, and H2-receptor blockers. A recent effective addition to the treatment choices of PUD is potassium-competitive acid blockers (P-CABs), such as P-CAB vonoprazan.

Have you experienced any oral manifestations associated with your disease?

Oral manifestations associated with PUD are not common, but oral dryness due to medications may be present.

If the patient experiences persistent regurgitation of gastric acid, palatal enamel erosion may be observed.

Oral manifestations of food allergies may be encountered as major aphthous stomatitis with elevated borders.

Peutz-Jeghers Syndrome is an autosomal dominant inherited disorder characterized by intestinal hamartomatous polyps in association with mucocutaneous melanocytic macules.

Medical Disorders
- Anemia
Oral Health Care Considerations
- Peptic Ulcer Disease
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